33 articles - From Friday Jan 10 2025 to Friday Jan 17 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| J Crohns Colitis |
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Diagnosing Crohn's Disease in Presumed Cryptoglandular Perianal Fistulas: An Expert Delphi Consensus on Early Identification of Patients at Risk of Crohn's Disease in Perianal Fistulas (PREFAB). International consensus was reached on a new, clinical decision tool, including a practical and relevant algorithm for finding/excluding CD in PAF patients. |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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Association between dietary fructose and human colon DNA methylation: implication for racial disparities in colorectal cancer risk using a cross-sectional study. Our data support that dietary fructose exerts a greater CRC risk-related effect in right than left colon among AA adults, alluding to its potential role in contributing to racial disparities in CRC. |
Determinants of Maternal and Infant Omega-3 Status at 3 Months Postpartum: Findings from the APrON Longitudinal Cohort Study. Maternal total dietary intake and pre-pregnancy BMI are independently associated with their serum fatty acid status during lactation, while maternal diet, milk fatty acid composition, and lactation status are important determinants of infant n-3 LCPUFAs fatty acid status. Future research should investigate the impact of these differences in fatty acid status on infant health outcomes. |
Dietary-Lifestyle Patterns and Colorectal Cancer Risk: Global Cancer Update Programme (CUP Global) Systematic Literature Review. Adopting a healthy pattern of diet, maintaining a healthy weight, staying physically active, and embracing health-conscious habits, such as avoiding tobacco and moderating alcohol, are collectively associated with a lower CRC risk. Healthy lifestyle habits are key to primary CRC prevention. |
Drivers of stunting and wasting across serial cross-sectional household surveys of children under 2 years of age in Pakistan: potential contribution of ecological factors. Apart from recognized multifactorial drivers of stunting and wasting among children such as poverty, food insecurity and maternal undernutrition, our analysis suggest the potential independent association with climatic factors such as heat and excess precipitation over time. These findings underscore the need for further research and potential integration of climatic mitigation and adaptation with nutrition response strategies. |
Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study. This study presents an explainable ML model for the early identification of PRCC that utilizes simple body weight dynamics. The findings showcase the potential of this approach in improving the management of cancer cachexia to optimize patient outcomes. Registration information Data described in the manuscript was derived from a registered research project (URL ID ChiCTR1800020329). |
Investigating eating architecture and the impact of the precision of recorded eating time: a cross-sectional study. Precise timing improves the estimation of eating architecture. Differences in estimation will affect descriptions of children's eating habits and possibly dietary guidance. However, consistent directional associations across timing methods, suggest that broad times could provide a pragmatic method for investigating eating architecture associations in large samples. |
Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies. Among individuals with T2D, a higher intake of lignans, particularly SECO, was significantly associated with reduced overall, CVD, and cancer mortality. Minority groups may particularly benefit from lignan intake, although further studies are warranted to substantiate this observation. |
Planetary Health Diet Index Trends and Associations with Dietary Greenhouse Gas Emissions, Disease Biomarkers, Obesity, and Mortality in the United States (2005-2018). These results underscore the potential health and greenhouse gas emission benefits aligned with the planetary health diet. |
Protein supplementation delivered alone or in combination with presumptive azithromycin treatment for enteric pathogens did not improve linear growth in Bangladeshi infants: results of a cluster-randomized controlled trial. Supplementation to increase intakes of high-quality protein, provided with or without presumptive treatment for enteric pathogens, did not improve linear growth from 6 to 12 months of age. |
| Inflamm Bowel Dis |
Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis. Our findings underscore a connection between IBD and CHIP pathophysiology. Patients with IBD and CHIP had unique risk profiles, especially among older UC patients and younger CD patients. These findings suggest distinct evolutionary pathways for CHIP in IBD and necessitate awareness among IBD providers and hematologists to identify patients potentially at risk for CHIP-related complications including malignancy, cardiovascular disease, and acceleration of their inflammatory disease. |
Impact of 5-Aminosalicylic Acid on Ustekinumab in Inflammatory Bowel Disease: A Retrospective Medical Claims Analysis. 5-ASA did not provide a significant overall benefit when used in combination with UST for CD or UC. However, post hoc subgroup analyses indicated a potential role for 5-ASA in specific subgroups. Further studies are necessary to confirm these findings and explore personalized treatment strategies. |
The Correlation Between Fecal Amino Acids, Colonic Mucosal Taste Receptors, and Clinical Features and Indicators of Ulcerative Colitis: A Multicenter Exploratory Study. The increased levels of taste receptors and fecal AAs in the colon of UC patients suggest an abnormal nutrient-sensing mechanism, potentially playing a crucial role in the development of the disease. |
Wound Healing After Vaginal Delivery, Episiotomy, and Cesarean Section Delivery Among Women With IBD: Results From the PIANO Registry. Episiotomy was a common occurrence in patients with IBD. Immunomodulator, but not biologic, use was found to be associated with delayed wound healing. This association could reflect a direct medication effect on episiotomy wound healing or inadequate treatment of underlying active disease prior to delivery. Vaginal tears were also common but delayed wound healing was not associated with IBD therapy. C-section occurred at high rates, particularly in Crohn's disease patients, with no reported delays in postpartum wound healing. |
hsa_circ_0015388 Reduces Macrophage Derived Reactive Oxygen Species in Crohn's Disease. A comprehensive analysis of circRNA expression revealed that 31 circRNAs were dysregulated in the CD group. Hsa_circ_0015388 is expressed in macrophages and negatively regulates ROS function inhibiting the TNFSF10 pathway. This study first revealed that hsa_circ_0015388 plays a role in the pathogenesis of CD by suppressing ROS production in macrophages. |
| J Crohns Colitis |
Childhood-onset inflammatory bowel disease and chronic non-bacterial osteomyelitis: A Swedish nationwide cohort study 2002-2022. We found a six-fold increased risk of CNO in childhood-onset IBD compared to non-IBD comparators. Patients with IBD+CNO are characterized by younger age at IBD onset, more frequent extraintestinal manifestations, and higher usage of biologics. |
Deconditioning in quiescent Crohn's Disease patients with heightened fatigue perception. CD self-reported increased fatigue perception and exhibited a slower rate of post-exercise PCr resynthesis compared to HV. This occurred independently of changes in body composition, muscle strength and fatigueability. IBD fatigue may be linked to peripheral muscle deconditioning and lower gmCBF during submaximal exercise. |
Durable remission after ileocolic resection for Crohn's disease is achievable in selected patients. Long-term results of a prospective multicentric cohort study of the GETAID Chirurgie. Surgery for CD achieved durable remission in 20%, rising to 40% in those with a B1 phenotype. These results support surgery as a viable alternative to medical treatment, offering treatment-free durable remission and preserving medical treatment options. |
Improvement in Serum Eosinophilia is Observed in Clinical Responders to Ustekinumab but not Adalimumab in Inflammatory Bowel Disease. Eosinophil reduction was identified as a marker for early response to ustekinumab in both UC and CD, but not adalimumab. No difference was observed among UC patients treated with vedolizumab either. Targeting the IL-12/IL-23 pathway may be more effective in managing eosinophil-associated inflammation in IBD. |
| Liver Transpl |
Racial and ethnic disparities in liver transplant access vary within and across transplant referral regions. We observed substantial geographic variation in the magnitude of racial disparities in liver transplant access across the United States. Findings highlight the need for targeted health equity interventions in regions with high disparities and the development of disparity-sensitive access metrics for transplant centers. |
Validation of mitochondrial FMN as a predictor for early allograft dysfunction and patient survival measured during hypothermic oxygenated perfusion. Low-risk grafts, according to FMN, display a negligible risk for patients. Yet, high-risk grafts are associated with increased risk for EAD, transplantation, and early mortality and should not be used for transplantation without further assessment. |
| Pancreatology |
Sequence analysis of the 5' region of the chymotrypsin C (CTRC) gene in chronic pancreatitis. However, the disease association was driven by the linkage disequilibrium with the known CTRC risk variant c.180C>T. We found no significant association between variants in the 5' region of the CTRC gene and CP risk. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Clin Nutr |
|---|
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
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| Liver Transpl |